Low-dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan.

• Tác giả: Motohiro Ebisawa, Tatsuki Fukuie, Komei Ito, Yasusuke Kawada, Yumi Koike, Katsushi Miura, Ken-Ichi Nagakura, Mizuho Nagao, Mika Ogata, Ikuo Okafuji, Yuki Sakaguchi, Sakura Sato, Kyohei Takahashi, Hiroaki Taniguchi, Noriyuki Yanagida
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.115 Logic programming
• Thông tin xuất bản: England : Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology , 2025
• Bộ sưu tập: NCBI
• ID: 749604

Tóm tắt

BACKGROUND: Few studies have reported significant risk factors for allergic symptoms during low-dose (1-3 mL) cow's milk (CM) oral food challenges (OFCs). We investigated patients from multiple centers in Japan to identify high-risk, low-dose CM OFCs and conducted these tests at allergy-specialized facilities. METHODS: We retrospectively collected the results of the first low-dose CM OFCs performed at 10 hospitals in Japan between January and December 2019. All patients completely eliminated CM and underwent low-dose CM OFCs. The risk factors for positive OFC and anaphylaxis were analyzed using logistic regression analyses. RESULTS: We included 244 patients (median age: 2.5 years). The median level of CM-specific immunoglobulin E (sIgE) was 13.1 (interquartile range: 3.7-45.6) kU CONCLUSION: CM and casein sIgE levels should be considered when predicting low-dose CM OFC outcomes.