Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice.

• Tác giả: Stephanie E Ander, Mariana O L da Silva, Bennett J Davenport, Erin R Fish, Thomas E Morrison, M Guston Parks
• Ngôn ngữ: eng
• Ký hiệu phân loại: 155.262 Classical typology (Hippocrates theory of temperaments)
• Thông tin xuất bản: United States : Journal of virology , 2025
• Bộ sưu tập: NCBI
• ID: 749635

Tóm tắt

Previously, we found that chimeric Sindbis-eastern equine encephalitis virus (SINV-EEEV) particles can be removed from the murine blood circulation in a phagocyte-dependent manner which can be disrupted by either transient depletion of vascular heparan sulfate (HS) glycosaminoglycans (GAGs), or mutation of the viral E2 glycoprotein (K71/74/77A) associated with decreased GAG binding