Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity.

• Tác giả: Lianru Chen, Zheng Li, Zhiling Liang, Zibin Liao, Chunxia Liu, Yuxia Liu, Jianming Mao, Die Ou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.7462 Communications, vehicles, sanitation, related topics
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 749776

Tóm tắt

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases, driven by diverse genetic and environmental factors. Extensive human genetics' studies have indicated that HSD17B13 is emerging as a promising therapeutic target for MASH. However, no