Genome Mining of Isoindolinone-Containing Peptide Natural Products.

• Tác giả: Wenyu Han, Tyler A Kerr, Yi Tang, Zuwei Wang, Lin Wu, Yalong Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.944 Monsters and related phenomena
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 749822

Tóm tắt

Peptide natural products (PNPs) are important sources of bioactive compounds. Recent studies have shown that oligopeptides or pseudopeptides can be synthesized by amide-bond-forming enzymes such as ATP-grasp enzymes and amide-bond synthetases (ABSs). By focusing on ATP-grasp enzymes as part of a conserved biosynthetic enzyme ensemble, genome mining of PNPs was performed on three biosynthetic gene clusters (BGCs) from diverse fungi, including