Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids

• Tác giả: Wen-Chao Gao, Ke-Xin Huang, Ting Li, Wen-Dian Li, Wen-Guang Li, Yong Teng, Jie Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 781.256 *Harmonic rhythm
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 749871

Tóm tắt

Dual-nickel/photoredox-catalyzed aromatization-mediated deconstruction and acylation of spiro-dihydroquinazolinones with carboxylic acids serving as acyl electrophiles is described. A series of synthetical ketone scaffolds with functional group tolerance could be obtained under mild conditions. A radical pathway involving an N-centered radical inducing β-scission to form a C-centered radical is proposed for these transformations.