In petroleum extraction, acidizing agents can enhance reservoir permeability but severely corrode metal equipment. Traditional acidizing corrosion inhibitors exhibit poor thermal stability at high temperatures, being prone to decomposition or denaturation, which significantly diminishes their film-forming and corrosion-inhibiting capabilities. In contrast, ionic liquid corrosion inhibitors demonstrate exceptional thermal stability under extreme conditions, making them a highly promising alternative. Through the innovative integration of multiscale mechanistic research methodologies, this study systematically evaluated the corrosion inhibition performance of six acidizing inhibitors using weight loss tests, complemented by electrochemical analysis, quantum chemical calculations, molecular dynamics simulations, adsorption energy analysis, surface characterization, and adsorption thermodynamic studies. The electrochemical tests indicate that the corrosion inhibitor exhibits inhibitory effects on both the anodic and cathodic corrosion processes, classifying it as a mixed-type inhibitor. Quantum chemical calculations revealed the interaction mechanism between inhibitor molecules and metal atoms, characterized by electron donation from inhibitor molecules and electron acceptance by metal atoms. Thermodynamic analysis reveals that the adsorption process conforms to the Langmuir model (