Tandem process of asymmetric organocatalysis and selective post-functionalization: enantiodivergent synthesis of bioactive indane-1-carboxylic acid derivatives.

• Tác giả: Alexander A Korlyukov, Ruslan A Kovalevsky, Alexander S Kucherenko, Madina Zhanabaeva, Sergei G Zlotin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 940.53185092 1918
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 750235

Tóm tắt

The first practical enantiodivergent synthesis of bioactive indane-1-carboxylic acid derivatives is developed. A key step of the synthesis is highly enantioselective organocatalytic Michael addition of allomaltol, an available natural kojic acid derivative, to 1