PURPOSE: To assess the efficacy and safety of repeated low-level red-light (RLRL) therapy in controlling myopia progression among multi-ethnic school-aged children. This report focuses on interim three-month data analysis. METHODS: A multi-ethnic, parallel controlled randomized trial. Thirty-four children aged 8-13 years with myopia were enrolled. Participants were randomly assigned to the RLRL group ( RESULTS: A total of 32 (94.1%) participated in the three-month follow-up visit. The RLRL group demonstrated a significant shortening in AL ( - 0.06 ± 0.05 mm) compared to the SVS group (0.02 ± 0.06 mm, CONCLUSIONS: The three-month interim analysis shows that RLRL therapy effectively controls myopia progression among multi-ethnic children without safety concerns, suggesting its potential as a globally applicable solution for myopia control.