BACKGROUND: There is limited literature on tumor location of uveal melanoma (UM) and the relative impact on metastasis-free survival (MFS). METHODS: A review of 1002 consecutive eyes with UM was performed and precise tumor location was identified according to quadrant (5 zones), clock hour (13 zones), anteroposterior (5 zones), and a combination of clock hour and anteroposterior regions (49 zones). Heat maps were constructed for frequency in each zone and Kaplan-Meier estimates for 5- and 10-year MFS was calculated. RESULTS: The UM quadrant regions included central (macula and juxtapapillary) (18%), superior (19%), nasal (18%), inferior (18%), and temporal (27%). The central region demonstrated smaller UM thickness ( CONCLUSIONS: Across all fundus regions, UM occurred most often in the central region. Uveal melanoma in the central region was smaller in thickness and base and demonstrated more favorable MFS compared to other quadrants, clock hours, and anteroposterior zones. Analysis of the 49 zones showed no benefit of tumor location alone after adjusting for tumor size and proximity to foveola and optic disc.