The Difficulties in Emotion Regulation Scale (DERS) is frequently used to assess emotion regulation (ER) capabilities. Originally a multidimensional scale, many utilize its total score, without clear recommendations. We aimed to explore the DERS's structure, dimensionality, and utility and provide clinicians and researchers with clear guidelines. Self-report data on ER, personality, psychopathology, and life satisfaction were collected from 502 adults. Seventy also participated in a lab study evaluating group interactions, which included additional self-report and physiological monitoring. Findings suggested favoring the correlated-traits and bifactor models, the latter excelling in direct comparisons. The total score was found reliable and valid, explaining 53.3% of the variance, with a distinct emotional awareness subfactor, suggesting a non-pure unidimensional solution. A cutoff score of 95 identified significant ER difficulties, linked to psychopathology. We thus recommend using the DERS's total score and 95 as its cutoff, while calling for further validation in diverse and clinical samples.