Cardiorespiratory, hemodynamic, and sedative effects of dexmedetomidine in sheep.

• Tác giả: Isabela Plazza Bittar, Leandro Guimarães Franco, Janainne Hilbig Gomes, Rauane Sousa de Moura, Bruna Ginú Prado
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.194 Radio
• Thông tin xuất bản: England : Laboratory animals , 2025
• Bộ sưu tập: NCBI
• ID: 751148

Tóm tắt

An alternative in an attempt to minimize the effects triggered by intravenous (IV) bolus administration of α-2 adrenergic receptor agonists are continuous rate infusions (CRI). The requirement for sedation protocols in sheep for procedures to be performed without physical restraint and with reduced adverse effects, commonly observed with bolus use, justifies the study of CRI. The aim of study was to compare the cardiopulmonary and sedative effects of IV bolus injection and CRI of dexmedetomidine (DEX) in sheep. Six adult male sheep (38.3 ± 7.6 kg) received DEX as a bolus (5 µg kg