Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.

• Tác giả: Gillian J Bedwell, Mark R Hutchinson, Peter Kamerman, Victoria J Madden, Luyanduthando Mqadi, Romy Parker
• Ngôn ngữ: eng
• Ký hiệu phân loại: 633.14 *Rye
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 751201

Tóm tắt

 Adversity in childhood elevates the risk of persistent pain in adulthood. Neuroimmune interactions are a candidate mechanistic link between childhood adversity and persistent pain. We aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in adults with a range of childhood adversity. Pain-free adults (n=96
  61 female
  median (range) age: 23 (18-65) years old) with a history of mild to severe childhood adversity underwent psychophysical assessments before and after