Structures of aberrant spliceosome intermediates on their way to disassembly.

• Tác giả: Olexandr Dybkov, Tamás Fischer, Dirk Flemming, Attila Horvath, Merlin Schwan, Irmgard Sinning, Komal Soni, Sasanan Trakansuebkul, Henning Urlaub, Klemens Wild
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.113 Structured programming
• Thông tin xuất bản: United States : Nature structural & molecular biology , 2025
• Bộ sưu tập: NCBI
• ID: 751640

Tóm tắt

Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have been revealed by combined structure-function analyses, structural information on an aberrant spliceosome committed to premature disassembly is not available. Here, we report two cryo-electron microscopy structures of post-B