Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

• Tác giả: Yassmin Al Aaraj, Mona Alotaibi, Daniel G Anderson, Sanya Arshad, Ivet Bahar, Raymond L Benza, Thomas Bertero, Stephen Y Chan, Caroline Chauvet, Mary Hongying Cheng, Susan Cheng, Miranda K Culley, Ankit A Desai, Samuel Detmer, Wadih El Khoury, Edward Guzman, Neha Hafeez, Kathleen J Haley, Lloyd D Harvey, Mohit Jain, Siyi Jiang, Neil J Kelly, Hee-Jung J Kim, Anna Kirillova, Robert Lafyatis, Ji Young Lee, Rajith S Manan, Jeffrey G McDonald, Vinny Negi, William C Nichols, S Mehdi Nouraie, Satoshi Okawa, Michael W Pauciulo, Dror Perk, Rashmi J Rao, Rajan Saggar, Tae-Hwi Schwantes-An, Claudette M St Croix, Donna B Stolz, Wei Sun, Yi-Yin Tai, Ying Tang, Bing Wang, Annie M Watson, Aaron B Waxman, Amy Webb, Chen-Shan C Woodcock, Haodi Wu, Rong Xie, Manling Zhang, Jingsi Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 395.142 Male
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 751674

Tóm tắt

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 (