Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres.

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Tác giả: Algemir Lunardi Brunetto, André Tesainer Brunetto, Matheus Dalmolin, Caroline Brunetto de Farias, Marcelo A C Fernandes, Natália Hogetop Freire, Lauro José Gregianin, Alice Laschuk Herlinger, Mariane da Cunha Jaeger, Carolina Nör, Vijay Ramaswamy, Rafael Roesler, Michael D Taylor, Julia Vanini

Ngôn ngữ: eng

Ký hiệu phân loại: 302.545 Isolation

Thông tin xuất bản: Switzerland : Cells , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 751694

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Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could be repurposed as an epigenetic anticancer therapy. Here, we show that VPA reduced medulloblastoma (MB) cell viability and led to cell cycle arrest. These effects were accompanied by enhanced H3K9 histone acetylation (H3K9ac) and decreased expression of the

1. Modulation
2. Of
3. Stemness

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