Pre-biologic FeNO might predict anti-IL-5/IL-5Rα response to treatment in severe asthmatics.

• Tác giả: Stefano Baglioni, Elena Bargagli, Paolo Cameli, Gianna Camiciottoli, Giovanna Elisiana Carpagnano, Carlo Cavaliere, Angelo Guido Corsico, Leonardo Gianluca Lacerenza, Mauro Maniscalco, Simonetta Masieri, Pierluigi Paggiaro, Corrado Pelaia, Girolamo Pelaia, Antonio Perrella, Dejan Radovanovic, Alberto Ricci, Paola Rogliani, Pierachille Santus, Marco Scalese, Nicola Scichilone, Bruno Sposato
• Ngôn ngữ: eng
• Ký hiệu phân loại: 386.44 Canals connecting Atlantic and Pacific Oceans
• Thông tin xuất bản: England : The Journal of asthma : official journal of the Association for the Care of Asthma , 2025
• Bộ sưu tập: NCBI
• ID: 752224

Tóm tắt

 OBJECTIVE: It remains unclear whether baseline FeNO levels can predict response to anti-IL5/5R biologic treatment in patients with severe asthma. METHODS: We recruited 104 patients with severe eosinophilic asthma treated with anti-IL5/anti-IL5R for at least one year who had measured FeNO values before the beginning of anti-eosinophilic treatment. Population was divided into subjects with FeNO <
  25 and ≥25 ppb. In each group we evaluated the changes in pulmonary function (FEV RESULTS: FEV CONCLUSION: Pre-biologic FeNO might predict a greater response to treatment with anti-IL-5/5R especially in terms of lung function and OC sparing in subjects with severe eosinophilic/allergic asthma. This could likely be a biomarker that can better guide in choosing an anti-IL5/5R in severe overlapping asthma (eosinophilic/allergic) to maximize treatment effects.