Molecular insights into kinetic stabilization of amorphous solid dispersion of pharmaceuticals.

• Tác giả: Vladislav Aulich, Ctirad Červinka, Michal Fulem, Jan Ludík
• Ngôn ngữ: eng
• Ký hiệu phân loại: 523.019 Molecular, atomic, nuclear physics
• Thông tin xuất bản: England : Physical chemistry chemical physics : PCCP , 2025
• Bộ sưu tập: NCBI
• ID: 752488

Tóm tắt

Poor aqueous solubility of crystalline active pharmaceutical ingredients (APIs) restricts their bioavailability. Amorphous solid dispersions with biocompatible polymer excipients offer a solution to overcome this problem, potentially enabling a broader use of many drug candidate molecules. This work addresses various aspects of the