Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle.

• Tác giả: Han Dong, Chien-Yung Huang, Yifan Lyu, Shih-Yin Tsai
• Ngôn ngữ: eng
• Ký hiệu phân loại: 578.68 *Rare and endangered species
• Thông tin xuất bản: United States : Autophagy , 2025
• Bộ sưu tập: NCBI
• ID: 752773

Tóm tắt

Postmitotic skeletal muscle critically depends on tightly regulated protein degradation to maintain proteomic stability. Impaired macroautophagy/autophagy-lysosomal or ubiquitin-proteasomal protein degradation causes the accumulation of damaged proteins, ultimately accelerating muscle dysfunction with age. While