Helical polymer-containing bottlebrush polymers (BBPs) are a special and fascinating type of polymer. They possess bottlebrush topology and contain helical polymers as main chains (MCs) or side chains (SCs), thereby presenting interesting and fantastic properties, such as chiral amplification, circularly polarized luminescence, photonic crystal, and so on. This review mainly focuses on BBPs containing helical polymers of polypeptides, polyacetylenes (PAs), and polyisocyanides (PIs). Detailed summarizations are severally given to BBPs with helical polypeptides as MCs and SCs. Meanwhile, BBPs comprising helical PAs as MCs are fully discussed. What's more, BBPs consisted of helical PIs as MCs and SCs are described separately. In addition, BBPs with other helical polymers are briefly introduced, too. The authors hope this review will motivate more interest in developing helical polymers with complex topologies and fascinating properties, and encourage further progress in functional chiral materials.