Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury.

• Tác giả: Jonathon Chon Teng Chio, Michael G Fehlings, Nader Hejrati, James Hong, Mohamad Khazaei, Zijian Lou, Narihito Nagoshi, Alex Post
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577 Ecology
• Thông tin xuất bản: England : Stem cells translational medicine , 2025
• Bộ sưu tập: NCBI
• ID: 752997

Tóm tắt

Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.