Work-related medical rehabilitation is a multimodal, interprofessional program that reduces health-related discrepancies between job capacities and demands in order to support work participation of patients who are at an increased risk of failing to return to work (e. g. due to long-term sickness absence). The review outlines screening for patients who should be reached, diagnostics and treatments during work-related medical rehabilitation and evidence on the effectiveness of these programs. Moreover, tools supporting implementation of work-related medical rehabilitation are discussed.