BACKGROUND & AIMS: Time-restricted eating (TRE) shows promise for weight loss and improving menopause-related body composition and cardiometabolic health, but its effects on skeletal muscle tissue (SMT) in postmenopausal women are unknown. This study investigates the effects of three weight loss interventions over 12 weeks on SMT quantity, quality, function, and cardiometabolic health in postmenopausal women with overweight/obesity, with effects persistence evaluated at a 12-month follow-up. METHODS AND RESULTS: In this randomized controlled trial, 78 postmenopausal women (50-65 years
BMI 25-40 kg/m PRIMARY OUTCOME: Change in SMT quantity measured by MRI at baseline and after 12 weeks. SECONDARY OUTCOMES: intermuscular adipose tissue (IMAT), strength, power, body weight and composition, and cardiometabolic risk factors. CONCLUSION: This study will illustrate the effects of TRE and TRE combined with resistance exercise compared with the currently recommended obesity-lifestyle treatment on SMT quantity, quality, function, and cardiometabolic markers. The results will offer insights into dietary strategies to combat obesity and metabolic diseases without increasing sarcopenia risk in postmenopausal women, a sparsely studied and particularly affected population.