BACKGROUND: An increasing number of vaccine-related severe cutaneous adverse reactions (SCARs) have been reported in the literature. OBJECTIVES: To provide comprehensive information on the clinical spectrum of vaccine-associated SCARs. METHODS: This was a systematic review and meta-analysis of case reports, case series, cohort studies, case-control studies, and post-market surveillance data on SCARs following vaccination. Data were extracted on demographic information, vaccine types, past medical history, medication use, and SCAR types, manifestations, management, and prognosis. The SCARs examined included acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and generalized bullous fixed drug eruptions. RESULTS: A total of 255 cases of SCARs following vaccination were identified. Of these, 231 (91%) were classified as SJS/TEN. The pooled incidence of SCARs following vaccination was 1.676 per million (95% confidence interval = 0.136-20.668
I CONCLUSIONS: SCARs following vaccination are extremely rare, with SJS/TEN comprising the majority of reported cases. The most frequently suspected vaccine culprits include H1N1, influenza, varicella, and COVID-19 vaccines, particularly mRNA vaccines. However, concurrent medication use may confound the attribution of SCARs to vaccines.