Traditional health care models lack capacity to address the complex intersections of social, mental, emotional, and physical health and well-being. Adverse childhood experiences (ACEs) are common and can negatively affect lifelong physiology at molecular, cellular, and organ levels. Therefore, it is critical to address ACEs, support positive childhood experiences, and create services that promote holistic well-being. The Center for Resiliency and Wellbeing's (CRW) novel approach to care includes surveilling and screening for adversity, providing integrated and integrative services (I and I model), and changing the culture of health care through education and research. Since 2020, approximately 1,300 unique patients have been cared for by the CRW. The CRW team focuses on the human stress response, integrative care education, and trauma-specific mental health approaches. Early recognition and intervention for ACEs can impart immense personal and population benefits. The I and I model promotes healthy development, stable and nurturing relationships, and skill-building to improve lifelong health and well-being.