Over-expression of AeWRKY2 promotes oleanolic acid and hederagenin accumulation in Aralia elata.

• Tác giả: Wa Gao, Wenhua Guo, Zhe Li, Hongfei Liu, Yaru Liu, Ye Liu, Tuya Siqin, Lei Tao, Honghao Xu, Haoze Ying, Xiangling You, Yi Zhang, Yue Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.746 Data compression
• Thông tin xuất bản: France : Biochimie , 2025
• Bộ sưu tập: NCBI
• ID: 753803

Tóm tắt

Oleanolic acid (OA) and hederagenin from Aralia elata have important medicinal value due to their anti-cancer and anti-inflammatory activities. Transcription factors (TFs) can affect the production of active substances by regulating the expression of genes in metabolic pathways. In this study, a transcription factor AeWRKY2 was cloned and overexpressed in A. elata. The result of gene expression analysis and high-performance liquid chromatography (HPLC) showed that the key enzyme genes of all transgenic strains analyzed were up-regulated to varying degrees. The contents of oleanolic acid and hederagenin were higher than those of wild type, up to 2.773 mg g