Platelet hitchhiking vascular-disrupting agents for self-amplified tumor-targeting therapy.

• Tác giả: Hongyu Chu, Xuedong Fang, Yuezhan Shan, Na Shen, Mengmeng Sun, Zhaohui Tang, Yajun Xu, Weidong Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 213 Creation
• Thông tin xuất bản: England : Journal of nanobiotechnology , 2025
• Bộ sưu tập: NCBI
• ID: 76448

Tóm tắt

The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hindered by nonspecific targeting and significant cardiovascular toxicity. This study introduces a novel self-amplified tumor-targeting delivery system(P@NPPD)comprising azide-functionalized poly(ethylene glycol)-b-poly-[(N-2-hydroxyethyl)-aspartamide]-DMXAA (N