BACKGROUND/OBJECTIVES: This study aims to determine the level of anxiety, depression, and sleep disturbances in patients with chronic kidney disease, as well as the interactions between the three comorbidities, and the implications it has for health practitioners. METHODS: A descriptive cross-sectional study, following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines, was implemented whereby 179 patients with chronic kidney disease attending a government hospital were recruited to this study. RESULTS: Our results showed that 65.9% of the participants had the metrics of severe anxiety while 34.1 percent had moderate anxiety. Further, it was reported that more than half 51.4% of participants had poor sleep quality. The levels of depression reported by the patients were roughly 40.2% minimal depression, 29.6% mild, 21.2% moderate, and 8.9% depression that was severe. There was a significant correlation between mental health disease together with sociodemographic variables such as gender, marital status, educational status, and nationality ( CONCLUSION: Our findings illustrate the importance of more frequent early mental health measures and strategies that help patients with chronic kidney diseases. The main study limitation was the cross-sectional design, which allows for correlational but not causal statements to be made. We address a gap in the literature with our results by noting specific demographic characteristics that are associated with poor mental health in chronic kidney disease populations and discuss practical and policy recommendations aimed at enhancing the mental well-being of chronic kidney disease patients.