Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases.

• Tác giả: Khursheed Ahmed, Bernhard Biersack, Angela Corona, Olivier Delelis, Vijay H Masand, Federica Putzu, Clémence Richetta, Rainer Schobert, Enzo Tramontano, Nhat Quang Tu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 213 Creation
• Thông tin xuất bản: Switzerland : Molecules (Basel, Switzerland) , 2025
• Bộ sưu tập: NCBI
• ID: 78453

Tóm tắt

There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity. An HIV-1-RNase H assay was used to study the RNase H inhibition by the test compounds. Docking of active derivatives into the active site of the enzyme was carried out. Compounds