Glazing is a common method for smoothing the surface of zirconia and imitating the appearance of natural teeth. Several authors have previously reported that glazing reduces the strength of zirconia. However, the dependence of strength on glaze thickness and the mechanism of strength reduction remains unclear. Clarifying these factors is particularly important for improving the reliability of zirconia prostheses. In this study, three types of zirconia were glazed with various thicknesses, and their strength was evaluated. The results showed that the strength of the materials decreased with increasing glaze thickness. The decrease in the fracture load of the glazed test specimen stopped at a load where the stress necessary to fracture the glaze material was applied to the surface of the glaze layer. Furthermore, the strength reduction mechanism was investigated using FEM analysis, fractography, and Raman spectroscopy. The results suggested that the strength reduction due to glazing was a consequence of the crack-tip stress concentration developed upon the preliminary fracture of the glaze layer.