The crop yield can be affected by many factors, including various levels of weed presence. Therefore, we conducted a study to evaluate the effect of time of weed removal in combination with planting pattern and pre-emergence-applied herbicides on maize yield and yield components in 2015, 2016 and 2017. The experiments were designed in a split-split plot arrangements with three replications, which consisted of the two main plots (standard/conventional and twin-row planting pattern), two subplots (with and without pre-emergence herbicide application) and seven sub-subplots (seven weed removal timings). In the dry season of 2015, maize yield was much lower (413-9045 kg ha