A Gemini Virus-Derived Autonomously Replicating System for HDR-Mediated Genome Editing of the

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Bhabesh Borphukan, Dhirendra Fartyal, Donald James, Muslima Khatun, Malireddy K Reddy

Ngôn ngữ: eng

Ký hiệu phân loại: 171.8 Systems based on altruism

Thông tin xuất bản: Switzerland : Plants (Basel, Switzerland) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 78763

CRISPR/Cas9-mediated homology-directed repair (HDR) is a powerful tool for precise genome editing in plants, but its efficiency remains low, particularly for targeted amino acid substitutions or gene knock-ins. Successful HDR requires the simultaneous presence of Cas9, guide RNA, and a repair template (RT) in the same cell nucleus. Among these, the timely availability of the RT at the double-strand break (DSB) site is a critical bottleneck. To address this, we developed a sequential transformation strategy incorporating a deconstructed wheat dwarf virus (dWDV)-based autonomously replicating delivery system, effectively simplifying the process into a two-component system. Using this approach, we successfully achieved the targeted editing of the
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH