The Use of Antimicrobials in Animal Husbandry as a Potential Factor for the Increased Incidence of Colorectal Cancer: Food Safety and Kinetics in a Murine Model.

• Tác giả: Loredana Baldi, Antonio Barbieri, Giorgia Borriello, Roberta Brunetti, Francesca Bruzzese, Stefania Cavallo, Rosa D'Ambrosio, Marianna D'Amore, Barbara Degli Uberti, Maria Dimatteo, Sara Lambiase, Orlando Paciello, Giuseppe Palma, Rubina Paradiso, Roberta Pellicanò, Domenica Rea, Francesco Paolo Serpe, Emanuela Vaccaro
• Ngôn ngữ: eng
• Thông tin xuất bản: Switzerland : Animals : an open access journal from MDPI , 2025
• Bộ sưu tập: NCBI
• ID: 78809

Tóm tắt

 The aim of this research was to investigate the effects of the prolonged use of the broad-spectrum antimicrobial widely used in animal husbandry. By means of a mouse model, a translational study was carried out on immunocompetent mice (with a complete immune system). This study highlighted the effect of antimicrobial residues taken in with food on the growth time of cancer and on alterations to the gut microbiota. This project considered the fight against antimicrobial resistance from a One Health perspectivethrough collaboration between human medicine and veterinary medicine. Regarding food safety, antimicrobial residues in products of animal origin are rarely detected
  they therefore constitute a negligible factor in determining colorectal cancer.