Oxazolone-Induced Immune Response in Atopic Dermatitis Using a Goat Model and Exploration of the Therapeutic Potential of Pomegranate Peel Extract.

• Tác giả: Fawaz E Alanazi, Abdullah S Albalawi, Ahmad A Alharbi, Suhailah S Aljameel, Maha Abdullah Alwaili, Ahmed Elfadadny, Besheer G Elshafey, Mahmoud H Emam, Helal F Hetta, Ahmed S Mandour, Wedad M Nageeb, Rokaia F Ragab, Haney Samir
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.0795 Diseases
• Thông tin xuất bản: Switzerland : Animals : an open access journal from MDPI , 2025
• Bộ sưu tập: NCBI
• ID: 78903

Tóm tắt

Atopic dermatitis (AD) remains a challenging condition, necessitating effective models for investigation and therapeutic exploration. In this study, we employed a goat skin model to assess the immune response triggered by topical oxazolone (OX) application. The OX simulates a Th2-driven immune reaction typified by elevated Th2 cytokine (IL-4 and IL-13) expression and the infiltration of mononuclear cells magnified by the presence of CD3