INTRODUCTION: Human immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understanding. Our systematic review and meta-analysis aimed to synthesize associations between HIV and myocardial fibrosis from CMR-based observational studies in adults. METHODS: We identified 12 studies (2013-2024) with 1,769 participants [1,117 people with HIV (PWH)]. Three studies were cohort and nine were cross-sectional. Meta-analysis included seven studies on late gadolinium enhancement (LGE) (1,081 participants: 669 PWH), eight on native T1 mapping (840 participants: 467 PWH), and ten on ECVF (1,603 participants: 992 PWH). We examined myocardial fibrosis prevalence via the prevalence difference in LGE, and severity by mean differences in native T1 mapping values [milliseconds (ms)] and global extracellular volume fraction (ECVF,%) between PWH and HIV-uninfected individuals, using random effects model. RESULTS AND DISCUSSION: Pooled analyses showed PWH had a 33% higher prevalence of LGE (95% CI: 12.0%-54.0%, I SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=533379, CRD [42024533379].