Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs.

• Tác giả: Rana Abdelaziz, Mohammad Abdel-Halim, Mthandazo Dube, Peter Imming, Lea Mann, Norbert Reiling, Adrian Richter, Dina Robaa
• Ngôn ngữ: eng
• Ký hiệu phân loại: 006.54 *Speech synthesis
• Thông tin xuất bản: Switzerland : Molecules (Basel, Switzerland) , 2025
• Bộ sưu tập: NCBI
• ID: 80565

Tóm tắt

Ethambutol (EMB) is a first-line anti-tuberculosis drug that is also considered in treatment regimens for infections caused by non-tuberculous mycobacteria (NTM). EMB targets the arabinosyl transferases EmbCAB, which are important for the synthesis of cell wall constituents. To further explore and narrow down the structural variability of EMB, we synthesized three series of new EMB analogs. We tested their activity against