Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.

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Tác giả: Jiangbei Cao, Yiwei Chen, Xiulong Feng, Chao Han, Yiwei Hu, Zhuangde Jiang, Shengtao Li, Dingxin Liu, Mujie Liu, Na Liu, Zhijie Liu, Guanghao Lu, Waqar Ali Memon, Lihong Qi, Yuping Quan, Shareen Shafique, Yuxuan Shang, Yuping Shen, Jiajie Song, Haodong Wang, Wen Wang, Xuefeng Wang, Yuheng Wang, Zhixiang Wei, Xiaodong Wu, Xiaoyu Zhang, Yaqing Zhang, Yifan Zhao, Kun Zhou, Xin Zou

Ngôn ngữ: eng

Ký hiệu phân loại: 338.54 Economic fluctuations

Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 86943

In this study, an electret-inspired, charge-injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar-free healing of bacteria-infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret-like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis. In a mouse model of second-degree burns infected with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the hydrogel accelerates wound healing by 32% and reduces bacterial load by 60%, significantly inhibited scar formation by 40% compared to controls. QOSP hydrogel modulates the Th1/Th2 immune balance toward a Th1-dominant antifibrotic state through quaternized chitosan, thereby reducing collagen deposition by 35%. Electro-dielectric characterization reveals a dielectric constant of 6.2, a 34% improvement in conductivity (3.33 × 10
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