Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.

• Tác giả: Robert E Campbell, Neela Codadu, Olga Kopach, Daman Rathore, Dmitri A Rusakov, Leonid P Savtchenko, Yi Shen, Olga Tyurikova, Kirill Volynski, Sheng-Yi Wu, Rob C Wykes, Kaiyu Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.28 Auxiliary techniques and procedures; apparatus, equipment, materials
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 87392

Tóm tắt

Intense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest into the underlying mechanisms. We find that the Kir4.1 level in individual astrocytes sets the kinetics of their potassium and glutamate uptake current. Combining electrophysiology with multiplexed optical sensor imaging and FLIM reveals that rises in extracellular potassium would normally boost presynaptic Ca