T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome.

• Tác giả: Jinqian Li, Li Sun, Hang Xu, Yan Zhao, Hanshuo Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 599.6332 *Ungulates
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 87497

Tóm tắt

Type III secretion system (T3SS) is a virulence apparatus existing in many bacterial pathogens. Structurally, T3SS consists of the base, needle, tip, and translocon. The NLRC4 inflammasome is the major receptor for T3SS needle and basal rod proteins. Whether other T3SS components are recognized by NLRC4 is unclear. In this study, using