With the ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its increasing adaptation to humans, several variants of concern (VOCs) and variants of interest (VOIs) have been identified since late 2020. These include Alpha, Beta, Gamma, Delta, Omicron parent lineage, and other variants. These variants may show distinct levels of virulence, antigenicity, and infectivity, which require specific defense and control measures. In this study, we propose an [Formula: see text] infectious disease model to simulate the spread of SARS-CoV-2 variants among the human population. We combine the proposed epidemic model and reported infected data of variants with physical information neural networks (PINNs) to develop a novel mechanism called VOCs-informed neural network (VOCs-INN). In our experiments, we found that this algorithm can accurately fit the reported data of the British Columbia (BC) province and its five internal health agencies in Canada. Furthermore, it can simulate observed or unobserved dynamics, infer time-dependent parameters, and enable short-term predictions. The experimental results also reveal variations in the intensity of control strategies implemented across these regions. VOCs-INN performs well in fitting and forecasting when analyzing long-term or multi-wave data.