Receptor clustering tunes and sharpens the selectivity of multivalent binding.

• Tác giả: Stefano Angioletti-Uberti, Tine Curk, Jure Dobnikar, Daan Frenkel, Zhaoping Xie
• Ngôn ngữ: eng
• Ký hiệu phân loại: 362.295 *Cannabis
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 89093

Tóm tắt

The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepness of the response threshold of cellular processes activated by multivalent binding. The mechanism is based on the possibility to modulate the attraction between membrane receptors. We use theory and simulations to show how tuning interreceptor attraction can enhance or suppress the binding of multivalent ligand-coated particles to surfaces. The changes in the interreceptor attraction less than the thermal energy