Bacterial vaginosis-driven changes in cervicovaginal immunity that expand the immunological hypothesis for increased HIV susceptibility.

• Tác giả: Bhavna H Chohan, Julien Dubrulle, Jessica B Graham, Jairam R Lingappa, Jennifer M Lund, Matthias Mack, Finn MacLean, Nelly Mugo, Kenneth Ngure, Nicole Potchen, Michelle C Sabo, Ayumi Saito, Lena K Schroeder, Jessica L Swarts, Irene Cruz Talavera, Katherine K Thomas, Adino Tesfahun Tsegaye, Sarah C Vick, Lakshmi Warrier
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 89384

Tóm tắt

Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that is prevalent among reproductive-age females worldwide. Adverse health outcomes associated with BV include an increased risk of sexually-acquired HIV, yet the immunological mechanisms underlying this association are not well understood. To investigate BV-driven changes to cervicovaginal tract (CVT) and circulating T cell phenotypes, participants with or without BV provided vaginal tract (VT) and ectocervical (CX) tissue biopsies and PBMC samples. High-parameter flow cytometry revealed an increased frequency of cervical conventional CD4