Edible flowers are becoming a popular addition to diets. As science has progressed, it has been proven that in addition to their aesthetic value, they possess pharmacological effects and health-promoting properties. Several edible flowers are used in medicine, and the available literature data indicate their broad biological activity. This review focuses on pharmacological knowledge about the neuroactive, antioxidant, and anti-inflammatory potential of 15 traditionally used edible flowers. It also describes their traditionally uses and summarizes research findings on their chemical composition.