AIM: This study aims to evaluate the efficacy of coated nanoparticles within orthodontic appliances as a novel strategy to enhance their antibacterial properties. MATERIAL AND METHODS: A systematic search for relevant articles published between 2013 and March 2024 was conducted across electronic databases including PubMed, Scopus, Web of Science, and EBSCOhost. Studies meeting pre-defined eligibility criteria were included and assessed for methodological quality. Data on the antibacterial activity of coated nanoparticles on orthodontic appliances was extracted from included studies. RESULTS: A range of antimicrobial agents, including metallic nanoparticles (silver, titanium dioxide, silver-platinum alloy, zinc oxide, copper oxide), and others like chitosan, quaternary ammonium-modified gold nanoclusters, titanium nitride doped with calcium phosphate, and graphene oxide, have been explored for incorporation into orthodontic materials. Studies have shown a significant boost in the antibacterial capacity of these materials compared to controls, suggesting promise for improved oral hygiene during orthodontic treatment. CONCLUSION: It can be concluded that incorporating nanoparticles into orthodontic appliances holds promise for enhancing their antibacterial properties. However, the studies displayed significant heterogeneity therefore, further research with standardized protocols for factors like nanoparticle size, concentration, and incorporation techniques across various orthodontic materials is crucial to guide future clinical applications. PROSPERO REGISTRATION: CRD42024521326.