The Efficiency of Brain-Derived Neurotrophic Factor Secretion by mRNA-Electroporated Regulatory T Cells Is Highly Impacted by Their Activation Status.

• Tác giả: Nathalie Cools, Amber Dams, Hans De Reu, Carole Faghel, Ibo Janssens, Yousra El Ouaamari, Stefanie Peeters, Jasper Van den Bos, Morgane Vermeulen, Inez Wens
• Ngôn ngữ: eng
• Ký hiệu phân loại: 201 Religious mythology, general classes of religion, interreligious relations and attitudes, social theology [all formerly 291.1]
• Thông tin xuất bản: Germany : European journal of immunology , 2025
• Bộ sưu tập: NCBI
• ID: 89891

Tóm tắt

Genetic engineering of regulatory T cells (Tregs) presents a promising avenue for advancing immunotherapeutic strategies, particularly in autoimmune diseases and transplantation. This study explores the modification of Tregs via mRNA electroporation, investigating the influence of T-cell activation status on transfection efficiency, phenotype, and functionality. For this CD45RA