BACKGROUND: Chronic rhinosinusitis (CRS) is an inflammatory disease characterized by persistent immune dysregulation, which presents considerable limitations in current medical therapy. OBJECTS: This study investigates a supramolecular gel (PSPD), which aims to minimize systemic adverse effects through local injection, provide long-lasting anti-inflammatory effects, and modulate the mucosal immune microenvironment. METHODS: The properties of PSPD were evaluated using rheological experiments. Biocompatibility assessments were conducted through CCK-8 and serum biochemical analyses. The balance between T RESULTS: Rheological assessments revealed that PSPD possesses excellent self-healing and slow-release properties. CCK-8 and serum biochemical assays indicated that PSPD demonstrated superior biocompatibility. In nasal polyps, PSPD significantly inhibited IL17 expression. In an Eosinophilic Chronic Rhinosinusitis (ECRS) rat model, treatment with PSPD led to significant alleviation of nasal mucosal congestion. Furthermore, PSPD modulated the proliferation of T CONCLUSION: This multifunctional gel effectively sustains the modulation of T