Image-guided patient-specific prediction of interstitial fluid flow and drug transport in solid tumors.

• Tác giả: Wim Ceelen, Charlotte Debbaut, Pim Pullens, Hooman Salavati
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Journal of controlled release : official journal of the Controlled Release Society , 2025
• Bộ sưu tập: NCBI
• ID: 89928

Tóm tắt

 Tumor fluid dynamics and drug delivery simulations in solid tumors are highly relevant topics in clinical oncology. The current study introduces a novel method combining computational fluid dynamics (CFD) modeling, quantitative magnetic resonance imaging (MRI
  including dynamic contrast-enhanced (DCE) MRI and diffusion-weighted (DW) MRI), and a novel ex-vivo protocol to generate patient-specific models of solid tumors in four patients with peritoneal metastases. DCE-MRI data were analyzed using the extended Tofts model to estimate the spatial distribution of tumor capillary permeability using the K