Ki-67 as a marker for differentiating borderline and benign phyllodes tumors of the breast: A meta-analysis and systematic review.

• Tác giả: Victoria Alzogaray, Mayara Bearse, Davi Said Gonçalves Celso, Ana Claudia Frota Machado de Melo Lopes, Maria L R Defante, Lucas Antônio Fernandes Torres
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Annals of diagnostic pathology , 2025
• Bộ sưu tập: NCBI
• ID: 89946

Tóm tắt

 Previously published studies raise the possibility of a link between breast phyllodes tumors (PT) grading and Ki-67 expression. In the current study, the authors conducted a literature review and meta-analysis to evaluate the association between the histological grades of PT and Ki-67 positivity, as well as the potential role of this immunomarker for the grading of PT. Observational studies grading PT and providing Ki-67 expression levels were retrieved from databases searches up to 11 August 2024, with 10 % or more of positive stromal cells being considered the cut-off point. A subgroup analysis included studies using the World Health Organization (WHO) criteria for PT grading. A total of 416 PT from 10 studies were included, with 25 % (106/416) showing increased Ki-67 expression. A significant association was found with increased Ki-67 expression in borderline PT compared to benign PT (OR 19.44
  CI 3.11-121.74
  P = 0.008
  I