Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors.

• Tác giả: Alicer K Andrew, Antoine Chaillon, Natalie Elphick, Ifeanyi J Ezeonwumelu, Julie Frouard, Ashley F George, Sara Gianella, Martin R Jakobsen, Xiaoyu Luo, Tongcui Ma, Jason Neidleman, Jesper G Pedersen, Magali Porrachia, Nadia R Roan, Davey M Smith, Reuben Thomas, Brendon Woodworth, Kailin Yin, Kyrlia C Young
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.453 Tin
• Thông tin xuất bản: United States : Cell reports , 2025
• Bộ sưu tập: NCBI
• ID: 90243

Tóm tắt

We developed viral sensor and restriction factor-cytometry by time of flight (VISOR-CyTOF), which profiles 19 viral sensors and restriction factors (VISORs) simultaneously in single cells, and applied it to 41 postmortem tissues from people with HIV. Mucosal myeloid cells are well equipped with SAMHD1 and sensors of viral capsid and DNA while CD4