PURPOSE: We aimed to analyze adolescent and young adults' (AYAs) perspectives on using sexually transmitted infection (STI) self-collection kits to help guide the provision and implementation of accessible and confidential reproductive health-care services for those who experience the burden of STIs and STI-related morbidity. METHODS: We utilized MyVoice, a nationwide text message survey of AYAs, to pose 6 open-ended questions on their perceptions and use of STI self-collection kits. Two independent reviewers used inductive content analysis to develop a codebook and analyze responses, and a third settled any coding discrepancies through discussion to reach consensus. Code frequencies and demographic data were summarized using descriptive statistics. RESULTS: We collected responses from 763 participants. Individuals who answered at least one question were included in the sample. Responses indicated that most (n = 695, 91.1%) participants would use free STI self-collection kits. Participants who would not use an STI self-collection kit (n = 45, 5.9%) cited concerns about test result accuracy and discomfort with specimen collection. DISCUSSION: Survey respondents were amenable to using free, STI self-collection kits
however, some were concerned about accuracy. There is an urgent need to prioritize and increase the accessibility of STI testing among youth. STI self-collection kits are an effective and accessible option that addresses barriers to reproductive health-care services-stigma, inconvenience, and lack of privacy. A social media campaign focusing on AYAs may increase knowledge and use of STI self-collection kits through dissemination of accurate information, stigma reduction, and provision of accessible resources that empower AYAs to prioritize their sexual health.