No QT interval prolongation effect of sepiapterin: a concentration-QTc analysis of pooled data from phase 1 and phase 3 studies in healthy volunteers and patients with phenylketonuria.

• Tác giả: Lan Gao, Nathalie H Gosselin, Yongjun Hu, Ronald Kong, Thomas Peyret, Neil Smith, Artem Uvarov
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.766 Drugs affecting reproductive system
• Thông tin xuất bản: United States : Journal of pharmacokinetics and pharmacodynamics , 2025
• Bộ sưu tập: NCBI
• ID: 90378

Tóm tắt

Sepiapterin is an exogenously synthesized new chemical entity that is structurally equivalent to endogenous sepiapterin, a biological precursor of tetrahydrobiopterin (BH